DNA loop extrusion is a method used to analyze how DNA is compacted into the nucleus whilst bringing regulatory elements close to protein coding genes. DNA, or deoxyribonucleic acid, is the genetic ...

It is one of the mysteries in biology: how does a cell neatly distribute its replicated DNA between two daughter cells? Scientists are split into two camps: the first argues that condensing works like ...

As it squeezes down the chromatin fiber, the cohesin protein complex extrudes a growing loop of DNA -- a bit like the quick-lacing system of trail-running shoes. But what is powering the movement of ...

A human cell carries in its nucleus two meters of spiraling DNA, split up among the 46 slender, double-helical molecules that are its chromosomes. Most of the time, that DNA looks like a tangled ball ...

How does a meter-long strand of DNA fit inside a cell without forming a tangled mess? This accomplishment comes courtesy of structural maintenance of chromosomes (SMC) proteins, which orchestrate the ...

Scientists from the Kavli Institute of Delft University of Technology and the IMP Vienna Biocenter discovered a new property of the molecular motors that shape our chromosomes. While six years ago ...

It's so impressive: a living cell is able to neatly package a big jumble of DNA, over two meters in length, into tidy, tiny chromosomes while preparing for cell division. For over a century, it has ...

To separate replicated sister chromatids during mitosis, eukaryotes and prokaryotes have structural maintenance of chromosome (SMC) condensin complexes that were recently shown to organize chromosomes ...

The paper M. Ganji et al., “Real-time imaging of DNA loop extrusion by condensin,” Science, doi:10.1126/science.aar7831, 2018. How does a human cell neatly pack ...

Researchers recorded the folding dynamics of the human genome over time, creating a novel 4-D map of genome organization. Simulation of DNA organized into two globules by loop extrusion. The figure-8 ...